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KMID : 1143620130170020048
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Korean Journal of Nuclear Medicine Technology
2013 Volume.17 No. 2 p.48 ~ p.52
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The Evaluation of Usefulness of 99Mo-99mTc Generator Using(n,γ)99Mo Developed by Korea Atomic Energy Research
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Seo Han-Gyeong
Kim Jeong-Ho
Sim Cheol-Min
Kim Byung-Cheol
Choi Do-Chul
Gwon Yong-Ju
Park Yung-Sun
Kim Dong-Yun
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Abstract
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Purpose: The Molybdenum which is the raw material of 99Mo-99mTc generator is produced from the nuclear reactor. However, output has dwindled as the two nuclear reactors supplying the bulk of radioactive material-one in Chalk River, Ontario and the other in Petten, the Netherlands-have been closed for repairs or maintenance. This resulted in the enhancement of its price. So 99Mo-99mTc generator using(n,γ) 99Mo is developed by Korea Atomic Energy Research Institute (KAERI). Medicinal availability of this generator is evaluated in this study.
Materials and Methods: The radioactivity of 99mTc eluted in generator 1, 2 and 3 unit developed by KAERI was measured. The quality control test of generator such as appearance test, pH test, LAL test, sterility test, chemical impurity (Al) test and radiochemical purity test were performed. Planar and SPECT/CT image sof SD rat (6 weeks, Female) at 2 hr after injection of 99mTc-HDP (hydroxymethylenediphosphonate) (TechneScan HDP, Malinckrodt Medical, Dutch) and 99mTc-DPD (diphosphono-1, 2-propanedicarboxylicacid) (TECEOS, CIS bio international, France) which were labeled with 99mTc eluted in KAERI and commercial generator (40.5 GBq, Malinckrodt Medical, Dutch) using SPECT/CT camera (Symbia, Siemense, Germany) were obtained respectively.
Results: The mean radioactivity of 99mTc elution generator 1unit was 4.18 GBq (113 mCi), generator 2 unit was 4.73 GBq (128 mCi) and generator 3 unit was 3.33 GBq (90 mCi). All quality control tests were within normal limit except pyrogentest. Pyrogen test was positive. Planar and SPECT/CT images of rat injected 99mTc-HDP which was labeled with 99mTc eluted in commercial generator show increased uptake in bone, stomach and bowl. Planar images show increased uptake in liver and bone in case of 99mTc-DPD. However, images of rat injected 99mTc-HDP and 99mTc-DPD which were labelled 99mTc eluted in KAERI generator show increased uptake in bone, liver and spleen.
Conclusion: If shortcoming is removed such as pyrogen and liver appearance, domestic role as an alternative generator is thought to be able to fill and to secure the national medical service by supplying 99mTc when the supply of 99mTc be comes short.
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KEYWORD
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Korea Atomic Energy Research Institute (KAERI) generator , (n, γ)
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